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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| GXXXXXXXXXXXXX | Kanamycin A |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00203 |
| Smiles | |
| Inchi Key | InChIKey=GNJQMIHYPFOBNE-VVFALJBOSA-N |
| Molecular weight | 3302.87 |
| Molecular formula | C145H255N43O40S2 |
| Chemical name | Peptide information |
| Sequence (one letter) | GXXXXXXXXXXXXX |
| Length | 14 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 1994357-15-1 |
| Other information | |
|---|---|
| Application | Antimicrobial therapy, antibacterial (Mycobacterium and Salmonela) |
| Additional function | Dual targeting, cell penetrating and nonmembrane lytic mechanism |
| Pharmacological class | antimicrobial, antibacterial |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Kanamycin A |
| Small molecule CAS | 59-01-8 |
| Small molecule structure | |
| Structure method | NMR COSY, TOCSY |
| Calculated properties | |
|---|---|
| LogP | -19.76857 |
| Rotatable bonds | 87 |
| H bond donor | 28 |
| H bond acceptor | 67 |
| Polar surface area (PSA) | 1260.09000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Dual Targeting of Intracellular Pathogenic Bacteria with a Cleavable Conjugate of Kanamycin and an Antibacterial Cell-Penetrating Peptide | 2016 | Brezden, Anna; Mohamed, Mohamed F.; Nepal, Manish; Harwood, John S.; Kuriakose, Jerrin; Seleem, Mohamed N.; Chmielewski, Jean | Journal of the American Chemical Society | ||
