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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| GXXXXXXXXXXXXX | Fluorescein |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00202 |
| Smiles | |
| Inchi Key | InChIKey=YXDRVJHWBRZNPB-DIDAIIFXSA-N |
| Molecular weight | 2974.67 |
| Molecular formula | C140H219N39O33 |
| Chemical name | Peptide information |
| Sequence (one letter) | GXXXXXXXXXXXXX |
| Length | 14 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 942941-28-8 |
| Other information | |
|---|---|
| Application | Antimicrobial therapy, antibacterial (Mycobacterium and Salmonela) |
| Additional function | Dual targeting, cell penetrating and nonmembrane lytic mechanism |
| Pharmacological class | antimicrobial, antibacterial |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Fluorescein |
| Small molecule CAS | 2321-07-05 |
| Structure method | NMR COSY, TOCSY |
| Calculated properties | |
|---|---|
| LogP | -11.14013 |
| Rotatable bonds | 71 |
| H bond donor | 20 |
| H bond acceptor | 55 |
| Polar surface area (PSA) | 1047.40000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Dual Targeting of Intracellular Pathogenic Bacteria with a Cleavable Conjugate of Kanamycin and an Antibacterial Cell-Penetrating Peptide | 2016 | Brezden, Anna; Mohamed, Mohamed F.; Nepal, Manish; Harwood, John S.; Kuriakose, Jerrin; Seleem, Mohamed N.; Chmielewski, Jean | Journal of the American Chemical Society | ||
