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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| GSXYSCFWKTCT | Combretastatin A4 |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01450 |
| Smiles | |
| Molecular weight | 1776.75 |
| Molecular formula | C84H112N16O23S2 |
| Chemical name | Peptide information |
| Sequence (one letter) | GSXYSCFWKTCT |
| Length | 12 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 566181-76-8 |
| Other information | |
|---|---|
| Application | Anticancer therapy and tumor imaging, radioisotope internalization |
| Additional function | Somatostatin receptor targeting |
| Pharmacological class | anticancer |
| Conjugate type | carbamate |
| Linker | no |
| Small molecule | Combretastatin A4 |
| Small molecule CAS | 117048-59-6 |
| Structure method | HPLC |
| Calculated properties | |
|---|---|
| LogP | -3.03459 |
| Rotatable bonds | 41 |
| H bond donor | 20 |
| H bond acceptor | 24 |
| Polar surface area (PSA) | 598.63000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
An adjustable release rate linking strategy for cytotoxin-Peptide conjugates | 2003 | Fuselier, Joseph A.; Sun, Lichun; Woltering, S. Nathaniel; Murphy, William A.; Vasilevich, Natalya; Coy, David H. | Bioorganic & Medicinal Chemistry Letters | ||
