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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| GPLGPAG | Doxorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01286 |
| Smiles | |
| Molecular weight | 1314.53 |
| Molecular formula | C67H78N8O20 |
| Chemical name | Peptide information |
| Sequence (one letter) | GPLGPAG |
| Length | 7 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 916686-32-3 |
| Other information | |
|---|---|
| Application | Anticancer therapy |
| Additional function | Targeting, matrix metalloproteinases (MMPs) expressed from tumors |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Doxorubicin |
| Small molecule CAS | 23214-92-8 |
| Structure method | HPLC |
| Calculated properties | |
|---|---|
| LogP | 1.46572 |
| Rotatable bonds | 23 |
| H bond donor | 11 |
| H bond acceptor | 19 |
| Polar surface area (PSA) | 404.50000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Peptide-doxorubicin conjugates specifically degraded by matrix metalloproteinases expressed from tumor | 2006 | Lee, Gee Young; Song, Ji-hye; Kim, Sang Yoon; Park, Kyeongsoon; Byun, Youngro | Drug Development Research | ||
