Use the buttons at the bottom of Jsmol viewer to see different representations, ON/OFF Hydrogens, and ON/OFF rotation.
3D model is for representation purpose only.
.
.
Schematic representation of peptide, linker and drug in the peptide-drug conjugates
 |
 |
 |
|
 |
|---|---|---|---|---|
| SRRARRSPRHLGSGC | Doxorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01250 |
| Smiles | |
| Molecular weight | 2220.06 |
| Molecular formula | C93H145N33O29S |
| Chemical name | Peptide information |
| Sequence (one letter) | SRRARRSPRHLGSGC |
| Length | 15 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 916443-68-0 |
| Other information | |
|---|---|
| Application | Antitumor therapy, colon and breast tumors |
| Additional function | improved efficacy and circumventing resistance |
| Pharmacological class | anticancer |
| Conjugate type | sulfide |
| Linker | no |
| Small molecule | Doxorubicin |
| Small molecule CAS | 23214-92-8 |
| Structure method | 1H NMR, HPLC |
| NMR solvent | DMSO-d6 |
| Calculated properties | |
|---|---|
| LogP | -18.42969 |
| Rotatable bonds | 63 |
| H bond donor | 39 |
| H bond acceptor | 47 |
| Polar surface area (PSA) | 1046.64000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Improved Therapeutic Efficacy of Doxorubicin through Conjugation with a Novel Peptide Drug Delivery Technology (Vectocell) | 2006 | Meyer-Losic, Florence; Quinonero, Jerome; Dubois, Vincent; Alluis, Bertrand; Dechambre, Mireille; Michel, Matthieu; Cailler, Francoise; Fernandez, Anne-Marie; Trouet, Andre; Kearsey, Jonathan | Journal of Medicinal Chemistry | ||
