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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| GRRRQRRKKRGGC | mercaptoacetic acid | 5′-O-Phosphonoadenylyl-(2′→5′)-adenylyl-(2′→5′)-adenosine |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01242 |
| Smiles | |
| Molecular weight | 3433.28 |
| Molecular formula | C132H188N56O45P4S |
| Chemical name | Peptide information |
| Sequence (one letter) | GRRRQRRKKRGGC |
| Length | 13 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 917877-33-9 |
| Other information | |
|---|---|
| Application | Antimicrobial, antiviral (HIV) |
| Additional function | peptide label with fluoresceine |
| Pharmacological class | abtimicrobial, antiviral |
| Conjugate type | sulfide |
| Linker | N/A |
| Linker Type | mercaptoacetic acid |
| Small molecule | 5′-O-Phosphonoadenylyl-(2′→5′)-adenylyl-(2′→5′)-adenosine |
| Small molecule CAS | 61172-40-5 |
| Structure method | 1H NMR |
| NMR solvent | CDCl3 |
| Calculated properties | |
|---|---|
| LogP | -17.69678 |
| Rotatable bonds | 91 |
| H bond donor | 50 |
| H bond acceptor | 73 |
| Polar surface area (PSA) | 1600.59000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Delivery of 2-5A cargo into living cells using the Tat cell penetrating peptide: 2-5A-tat | 2006 | Zhou, Longhu; Thakur, Chandar S.; Molinaro, Ross J.; Paranjape, Jayashree M.; Hoppes, Rieuwert; Jeang, Kuan-Teh; Silverman, Robert H.; Torrence, Paul F. | Bioorganic & Medicinal Chemistry | ||
