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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| NSATSSSGSGS | L-Serine-N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(5-β-D-glucopyranosyl-2,3-dihydroxybenzoyl)-L-seryl]-L-seryl]-(3→13)-lactone |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01116 |
| Smiles | |
| Molecular weight | 1753.56 |
| Molecular formula | C69H91N15O39 |
| Chemical name | Peptide information |
| Sequence (one letter) | NSATSSSGSGS |
| Length | 11 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 1000183-91-4 |
| Other information | |
|---|---|
| Application | Antibiotic, antibacterial |
| Additional function | Targeting of gramm-negative and multi-drug-resistant strains |
| Pharmacological class | antimicrobial, antibacterial |
| Conjugate type | amide |
| Linker | no |
| Small molecule | L-Serine-N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(5-β-D-glucopyranosyl-2,3-dihydroxybenzoyl)-L-seryl]-L-seryl]-(3→13)-lactone |
| Small molecule CAS | 851900-99-7 |
| Structure method | 1H NMR, LCMS |
| NMR solvent | CD3OD |
| Calculated properties | |
|---|---|
| LogP | -15.65151 |
| Rotatable bonds | 40 |
| H bond donor | 31 |
| H bond acceptor | 36 |
| Polar surface area (PSA) | 885.52000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Biosynthetic Tailoring of Microcin E492m: Post-translational Modification Affords an Antibacterial Siderophore-Peptide Conjugate | 2007 | Nolan, Elizabeth M.; Fischbach, Michael A.; Koglin, Alexander; Walsh, Christopher T. | Journal of the American Chemical Society | ||
