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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| GPLGIAGQ | Doxorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01078 |
| Smiles | |
| Molecular weight | 1519.66 |
| Molecular formula | C71H97N11O26 |
| Chemical name | Peptide information |
| Sequence (one letter) | GPLGIAGQ |
| Length | 8 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 646065-65-8 |
| Other information | |
|---|---|
| Application | Anticancer therapy |
| Additional function | targeting integrin, improving antitumor effect |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Doxorubicin |
| Small molecule CAS | 23214-92-8 |
| Structure method | 1H and13C NMR, HPLC |
| Calculated properties | |
|---|---|
| LogP | -3.59149 |
| Rotatable bonds | 40 |
| H bond donor | 14 |
| H bond acceptor | 26 |
| Polar surface area (PSA) | 541.32000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
In vitro and in vivo evaluation of doxorubicin conjugates with the divalent peptide E-[c(RGDfK)2] that targets integrin αvβ3 | 2008 | Ryppa, Claudia; Mann-Steinberg, Hagit; Fichtner, Iduna; Weber, Holger; Satchi-Fainaro, Ronit; Biniossek, Martin L.; Kratz, Felix | Bioconjugate Chemistry | ||
