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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| GPKKKRKV | 2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuransulfonamide |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00931 |
| Smiles | |
| Inchi Key | InChIKey=YFZUSHOBVKYRKV-FDWRCCRUSA-N |
| Molecular weight | 1647.99 |
| Molecular formula | C79H137N15O20S |
| Chemical name | Peptide information |
| Sequence (one letter) | GPKKKRKV |
| Length | 8 |
| Peptide name | nuclear localization sequences (NLS) |
| External ID | |
|---|---|
| CAS number | 1067653-24-0 |
| Other information | |
|---|---|
| Application | Anticancer therapy, photosensitizer |
| Additional function | Increased cell uptake via multiple nuclear localization sequences |
| Conjugate type | sulfonamide |
| Linker | no |
| Small molecule | 2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuransulfonamide |
| Small molecule CAS | 378230-81-0 |
| Small molecule structure | |
| Structure method | 1H NMR |
| NMR solvent | DMSO-d6 CDCl3 |
| Calculated properties | |
|---|---|
| LogP | 5.59416 |
| Rotatable bonds | 50 |
| H bond donor | 13 |
| H bond acceptor | 18 |
| Polar surface area (PSA) | 494.33000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Influence of the number and distribution of NLS peptides on the photosensitizing activity of multimeric porphyrin-NLS | 2010 | Sibrian-Vazquez, Martha; Jensen, Timothy J.; Vicente, M. Graca H. | Organic & Biomolecular Chemistry | ||
