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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| LTVSPWY | glutaric acid | Daunorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00720 |
| Smiles | |
| Inchi Key | InChIKey=WZIQXYMJRWSXRO-YGOKHFBXSA-N |
| Molecular weight | 1445.64 |
| Molecular formula | C72H91N11O21 |
| Chemical name | Peptide information |
| Sequence (one letter) | LTVSPWY |
| Length | 7 |
| Peptide name | ErbB-2-binding peptide |
| External ID | |
|---|---|
| CAS number | 1338681-74-5 |
| Other information | |
|---|---|
| Application | Anticancer therapy, HL-60 and HepG2 cell lines |
| Additional function | Targeting ErbB-2 receptor expressing tumors |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | glutaric acid |
| Small molecule | Daunorubicin |
| Small molecule CAS | 20830-81-3 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | 0.43241 |
| Rotatable bonds | 29 |
| H bond donor | 16 |
| H bond acceptor | 23 |
| Polar surface area (PSA) | 504.84000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
A New Daunomycin-Peptide Conjugate: Synthesis, Characterization and the Effect on the Protein Expression Profile of HL-60 Cells in Vitro | 2011 | Orban, Erika; Manea, Marilena; Marquadt, Andreas; Banoczi, Zoltan; Csik, Gabriella; Fellinger, Erzsebet; Bosze, Szilvia; Hudecz, Ferenc | Bioconjugate Chemistry | ||
