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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| QKYQPLDEKDKTLYDQFMLQQG | glycolic acid | 2-[2-oxo-2-[[4-[3-oxo-3-(2-oxo-1-azetidinyl)propyl]phenyl]amino]ethoxy] acetic acid |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00375 |
| Smiles | |
| Inchi Key | InChIKey=NQIBQXBGQQICEA-SMCFWDHXSA-N |
| Molecular weight | 3156.48 |
| Molecular formula | C143H209N33O46S |
| Chemical name | Peptide information |
| Sequence (one letter) | QKYQPLDEKDKTLYDQFMLQQG |
| Length | 22 |
| Peptide name | 22-mer peptide |
| External ID | |
|---|---|
| CAS number | 1024602-62-7 |
| Other information | |
|---|---|
| Application | Synthesis |
| Additional function | Manufacture of peptide?linker?antibody bioconjugates for the treatment of cancer |
| Pharmacological class | other |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | glycolic acid |
| Small molecule | 2-[2-oxo-2-[[4-[3-oxo-3-(2-oxo-1-azetidinyl)propyl]phenyl]amino]ethoxy] acetic acid |
| Small molecule CAS | 1024602-85-4 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -13.83858 |
| Rotatable bonds | 106 |
| H bond donor | 38 |
| H bond acceptor | 46 |
| Polar surface area (PSA) | 1262.85000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Chromatography- and Lyophilization-Free Synthesis of a Peptide-Linker Conjugate | 2014 | Magano, Javier; Bock, Brandon; Brennan, John; Farrand, Douglas; Lovdahl, Michael; Maloney, Mark T.; Nadkarni, Durgesh; Oliver, Wendy K.; Pozzo, Mark J.; Teixeira, John J.; Wang, Jian; Rizzo, John; Tumelty, David | Organic Process Research & Development | ||
