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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| RCKRWRWKWRW | propanamide | Doxorubicin & Curcumine |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00162 |
| Smiles | |
| Inchi Key | InChIKey=BDIOFZVHIQRJBP-PLESVWNQSA-N |
| Molecular weight | 2989.31 |
| Molecular formula | C147H184N32O33S2 |
| Chemical name | Peptide information |
| Sequence (one letter) | RCKRWRWKWRW |
| Length | 11 |
| Peptide name | [C(WR)4K2(b-A)] |
| External ID | |
|---|---|
| CAS number | 2148902-16-1 |
| Other information | |
|---|---|
| Application | Anticancer therapy, CCRF-CEM, SKOV-3, LLCPK cells |
| Additional function | Improve cell-penetration, nuclear targeting and solubility |
| Pharmacological class | anticancer |
| Conjugate type | disulfide |
| Linker | N/A |
| Linker Type | propanamide |
| Small molecule | Doxorubicin & Curcumine |
| Small molecule CAS | 23214-92-8 |
| Small molecule structure | |
| Small molecule CAS 2 | 458-37-7 |
| Small molecule structure 2 | |
| Calculated properties | |
|---|---|
| LogP | 2.27262 |
| Rotatable bonds | 66 |
| H bond donor | 35 |
| H bond acceptor | 45 |
| Polar surface area (PSA) | 1055.61000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Cyclic peptide conjugate of curcumin and doxorubicin as an anticancer agent | 2017 | Darwish, Shaban; Mozaffari, Saghar; Parang, Keykavous; Tiwari, Rakesh | Tetrahedron Letters | ||
