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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| LFMSCRTWKHYEQ | triazole |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00063 |
| Smiles | |
| Inchi Key | InChIKey=RJGCEYILJQWUHA-FAYRJNAXSA-N |
| Molecular weight | 2236.93 |
| Molecular formula | C102H136N26O26S3 |
| Chemical name | Peptide information |
| Sequence (one letter) | LFMSCRTWKHYEQ |
| Length | 13 |
| Peptide name | model peptide |
| External ID | |
|---|---|
| CAS number | 2247055-88-3 |
| Other information | |
|---|---|
| Application | Synthesis, cysteine-Selective conjugation to prepare antibody-drog conjugates |
| Additional function | Posible applications as various imaging and therapeutic conjugates |
| Pharmacological class | anticancer |
| Conjugate type | sulfide |
| Linker | N/A |
| Linker Type | triazole |
| Calculated properties | |
|---|---|
| LogP | -8.47782 |
| Rotatable bonds | 67 |
| H bond donor | 25 |
| H bond acceptor | 33 |
| Polar surface area (PSA) | 821.21000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
N-Methyl-N-phenylvinylsulfonamides for Cysteine-Selective Conjugation | 2018 | Huang, Rong; Li, Zhihong; Sheng, Yao; Yu, Jianghui; Wu, Yue; Zhan, Yuexiong; Chen, Hongli; Jiang, Biao | Organic Letters | ||
